NCSR - Demokritos
Welcome to the Institute of Microelectronics (IMEL) / NCSR "Demokritos"
Personnel of IMEL Dr Konstantinos Misiakos

   IMEL at a glance
   Organizational  Structure

 Funded Projects



   Research Papers
   Annual Report
 & Awards
  MiNASys Center of
  Nanotechnology and MEMS laboratory:
Access provided
 PhD programs
   Summer Schools
  Job Openings 
  News and Events
  Conferences & Workshops
  Contact Info

Dr Konstantinos Misiakos


Contact Information
Dr Konstantinos Misiakos
Director of Research
P.O.Box 60228
153 10 Aghia Paraskevi
Athens - GREECE

Tel: +30-2106503226
Fax: +30-2106511723


  • B.S. in Electrical Engineering at the National Technical University of Athens, Greece, November 1978.

  • M.S. in Electrical Engineering at Clemson University, Clemson, SC, May 1984.

  • Ph.D in Electrical Engineering at the University of Florida, Gainesville, FL, August 1987.


  • Graduate Research Assistant, Clemson University, SC, January 1983 - May 1984. Working on the reliability aspects of bipolar silicon devices.
  • Graduate Research Assistant, University of Florida, August 1984-August 1987. Working on modeling and characterization techniques for silicon bipolar devices.
  • Visiting Assistant Professor in electrical engineering at the University of Florida from August 1987 to May 1989. Since June 1989 researcher at the Microelectronics Inst. NCSR "Demokritos


  • Development of optical biosensors including monolithic optical imuunosensors and DNA sensors on Silicon.
  • Modeling, fabrication and experimental characterization techniques for bipolar devices and solar cells.
  • Design of CMOS VLSI low noise analog readout electronics for radiation imaging and spectroscopic systems.

Dr. Misiakos is the author or co-author of 80 publications in refereed international journals, of 42 communications in international conferences and holds three international patents on biosensors. He served as the coordinator of three European projects :  EU-BRITE III Project “BOEMIS” (1997-2000), EU-IST Project “BIOMIC” (2001-2004)  and the  EU-IST project "NEMOSLAB" (2006-2009), all in biosensors.


Recent Journal Papers

  • Mavrogiannopouloul E, Petrou PS, Kakabakos SE, K. Misiakos “Real-time detection of BRCA1 gene mutations using a monolithic silicon optocoupler array” : Biosensors & Bioelectronics   Vol. 24   Issue: 5   p. 1341-1347, 2009
  • Petrou PS, Kakabakos SE, Misiakos K: “Silicon optocouplers for biosensing” International Journal Of Nanotechnology   Volume: 6   Issue: 1-2   Pages: 4-17   Published: 2009
  • Niotis AE, Mastichiadis C, Petrou PS, Christofidis I, Siafaka-Kapadai A, Kakabakos SE, Misiakos K. “Capillary waveguide fluoroimmunosensor with improved repeatability and detection sensitivity”  Analytical And Bioanalytical Chemistry,   Volume: 393   Issue: 3   Pages: 1081-1086, 2009
  • Vlachopoulou ME, Tserepi A, Pavli P, Argitis P, Sanopoulou M, Misiakos K, “A low temperature surface modification assisted method for bonding plastic substrates”  Journal Of Micromechanics and Microengineering   Vol. 19,  015007, 2009
  • Misiakos K, Raptis I, Gerardino A, Contopanagos H. Kitsara “A monolithic photonic microcantilever device for in situ monitoring of volatile compounds”  Lab on a Chip,  Volume: 9   Issue: 9   Pages: 1261-1266   Published: 2009
  • Petrou, P., Ricklin, D., Zavali, M.,  Raptis I, Kakabakos SE, Misiakos K.,  Lambris, JD  “Real-time label-free detection of complement activation products in human serum by white light reflectance spectroscopy” Biosensors & Bioelectronics  Volume: 24   Issue: 11   Pages: 3359-3364, 2009
  • Mastichiadis  C., Petrou  P., Christofidis, I., Misiakos, K  Kakabakos, SE “Bulk fluorescence light blockers to improve homogeneous detection in capillary-waveguide fluoroimmunosensors” Biosensors & Bioelectronics, 24 , 8, pp. 2735-2739 , 2009
  • Niotis, A. Mastichiadis  C.,  Petrou, P. Siafaka-Kapadai, A  Christofidis, I  ; Misiakos, K  ; Kakabakos, SE “Ultra-thin poly(dimethylsiloxane) film-coated glass capillaries for fluoroimmunosensing applications” Microelectronic Engineering. 86,  4-6, 1491-1494 JUN 2009
  • Misiakos Konstantinos; Petrou P. Kakabakos  S.  “Fully integrated monolithic optoelectronic transducer for real-time protein and DNA detection: The NEMOSLAB approach” Biosensors & Bioelectronics, 26, 4,pp. 1528-1535, 2010
  • Mir, Monica; Kumar Dondapati, Srujan; Viviana Duarte, Maria Chatzichristidi, M,  Misiakos, K, Petrou, P, Kakabakos, SE, Argitis, P. Katakis, I: “Electrochemical biosensor microarray functionalized by means of biomolecule friendly photolithography” Biosensors & Bioelectronics, 25, 9, pp. 2115-2121, 2010
  • Kitsara, M.; Petrou, P.; Kontziampasis, D., Misiakos, K,  Makarona, E. Raptis, I.,  Beltsios, K  ; “Biomolecular layer thickness evaluation using White Light Reflectance Spectroscopy” Microelectronic Engineering, 87, 5-8, pp. 802-805   2010
  • Kitsara, Maria; Misiakos, Konstantinos; Raptis, Ioannis, Macarona E. “Integrated optical frequency-resolved Mach-Zehnder interferometers for label-free affinity sensing” Optics Express, 18, 8,   pp. 8193-8206, 12 2010
  • Niotis, A. Mastichiadis, C., Petrou, P. Christofidis, I., Kakabakos, SE., Siafaka-Kapadai, A. Misiakos, K.  “Dual-cardiac marker capillary waveguide fluoroimmunosensor based on tyramide signal amplification”  Analytical And Bioanalytical Chemistry, 396, 3, pp. 1187-1196, 2010
  • Zavali, M. Petrou, P. Goustouridis, D. Raptis, I. Misiakos, K.Kakabakos, SE. “A regenerable flow-through affinity sensor for label-free detection of proteins and DNA” Journal Of Chromatography B-Analytical Technologies In The Biomedical And Life Sciences, 878, 2, pp. 237-242, 2010
  • Oikonomou, P., Salapatas, A., Manoli, K., Misiakos, K., Goustouridis, D., Valamontes, E., Sanopoulou , "Chemocapacitance response simulation through polymer swelling and capacitor modelling”    Procedia Engineering 25 , pp. 423-426   2011
  • Maffeo, Davide; Velkov, Zhivko; Misiakos, Konstantinos; Mergia, K., Paulidou, A., Zavali, M,  Mavridis, IM., Yannakopoulou, K."Real-time monitoring of nanomolar binding to a cyclodextrin monolayer immobilized on a Si/SiO2/novolac surface using white light reflectance spectroscopy: The case of triclosan” Journal Of Colloid And Interface Science, 358,2,   pp.369-375, 2011
  • Misiakos, K."Monolithic silicon optocouplers for bio-chemical sensing" Procedia Engineering 25 , pp. 152-155 2011
  • Psarouli, A., Bourkoula, A., Petrou, P., Misiakos, K., Chaniotakis, N., Kakabakos, S "Covalent binding vs. adsorption of biomolecules on silicon nitride planar waveguides"    Procedia Engineering, 25 , pp. 350-353, 2011
  • Archontas, I.; Salapatas, A.; Misiakos, K."Molecular film growth monitoring via reflection microscopy on periodically patterned substrates" Optics Express,21,4,4215-4227, 2013
  • K. Misiakos "Diodes, Fundamentals and Transport Theory"  Chapter in Wiley Encyclopedia of Electrical and Electronics Engineering (W3120) in press, 2014

Recent Conference Papers

  • K. Misiakos, A. Botsialas, I. Raptis, E. Makarona, P. Petrou and S. Kakabakos, G. Jobst, R. Stoffer, M. Hoekman “Monolithically Integrated Frequency-Resolved Mach-Zehnder Interferometers for Highly-sensitive Multiplexed Label-free Bio/Chemical Sensing”, IEEE Sensors 2011 (Limerick, Ireland, 10/2011)
  • Konstantinos Misiakos. “Monolithic Silicon Optocouplers for Bio-Chemical Sensing”  Konstantinos Misiakos, Eurosensors 2011 (Athens, Sept. 4-7, 2011) (Invited)
  • E. Makarona, P. S. Petrou, A. Bourkoula, A. Botsialas, M. Kitsara, S. E. Kakabakos, R. Stoffer, G. Jobst, G. Nounesis, I. Raptis, K. Misiakos “Monolithically Integrated Mach-Zehnder Biosensors for Real-time Label-free Monitoring of Biomolecular Reactions”, 33rd Annual Int. Conf. IEEE EMBS (Boston, USA, 09/2011)(invited)
  • Raptis, E.Makarona, A.Botsialas, K.Misiakos, P.Petrou, A.Psarouli, S.Kakabakos, G.Jobst, M.Hoekman, R.Heideman, H.Leewuis, R.Stoffer, M.Sopanen, K.Tukkiniemi
  • “All-Silicon Optoelectronic Lab-On-a-Chip For Label-Free Multi-Analyte Biosensing:
    The PYTHIA Aproach” IC-MAST 2012, Budapest, Hungary, May 2012 (invited)
  • Konstantinos Misiakos, Eleni Makarona, Ioannis Raptis, Alex Salapatas, Aimilia Psarouli, Sotirios E. Kakabakos, Panayiota Petrou, Marcel Hoekman,  Remco Stoffer, PhoeniX B.V.; Kari Tukkiniemi,   Gerhard Jobst “Monolithic silicon interferometric optoelectronic devices for label-free multi-analyte biosensing applications”SPIE Photonics West, San Fransisco, February 2-7, 2013(invited)
  • K. Misiakos, E. Makarona, I. Raptis, A. Salapatas, A. Psarouli, S. Kakabakos, P. Petrou, M.Hoekman, R. Heidemac, R. Stoffer, K. Tukkiniemi, M. Soppanen, G. Jobst, G. Nounessis, A.Budkowski, J. Rysz “All-silicon Monolithic Optoelectronic Platform for Multi-analyte Biochemical Sensing” SPIE Microtechnologies Grenoble, France 24 - 26 April, 2013(invited)
  • Konstantinos Misiakos “Monolithic Silicon Photonic Transducers for the Detection of Biomolecules” IC4N, Corfu, Greece, June 16-20, 2013(invited)


back to top
NCSR - Demokritos